Preclinical Development Of A Neural Stem Cell Therapy For Stroke And Traumatic Brain Injury

Preclinical Development Of A Neural Stem Cell Therapy For Stroke And Traumatic Brain Injury by Emily Wyatt Baker. Download it Preclinical Development Of A Neural Stem Cell Therapy For Stroke And Traumatic Brain Injury books also available in PDF, EPUB, and Mobi Format for read it on your Kindle device, PC, phones or tablets. Stroke and traumatic brain injury (TBI) are leading causes of death and long-term disability worldwide.. Click Get Books for free books.

Preclinical Development Of A Neural Stem Cell Therapy For Stroke And Traumatic Brain Injury

Preclinical Development Of A Neural Stem Cell Therapy For Stroke And Traumatic Brain Injury
Author: Emily Wyatt Baker
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Stroke and traumatic brain injury (TBI) are leading causes of death and long-term disability worldwide. Despite the socioeconomic burden of these neural injuries, there are no restorative therapies. Induced pluripotent stem cell-derived neural stem cells (iNSCs) may be the critically needed therapy to restore neurological function after brain injury. Preclinical studies demonstrate that iNSCs are a multimodal therapeutic that improves recovery after neural injury. However, the enthusiasm of these results has been stifled by the hundreds of therapeutics shown to be effective in preclinical neural injury models but have failed in clinical trials, thus suggesting a lack of translatability of preclinical animal models to human patients. Compared to the rodent, the sole preclinical model iNSC therapy has been tested in, the pig possesses striking similarities in brain anatomy and physiology compared to the human and may be an ideal animal model to bridge the gap between preclinical rodent models and human patients. However, injury models and outcome measures are not well characterized in the pig, and more studies in the pig are needed to determine if large animals truly carry greater predictive power of clinical efficacy. The objectives of these studies were to 1) develop a translational pig model to study TBI pathophysiology and recovery mechanisms, and 2) assess whether iNSC therapy improves recovery in a pig stroke model. These studies strengthen current preclinical therapeutic development strategies for neural injury by improving the translational capacity of animal models and provide further insight into the potential of iNSC therapy for human patients.
Preclinical Development of a Neural Stem Cell Therapy for Stroke and Traumatic Brain Injury
Language: en
Pages: 550
Authors: Emily Wyatt Baker
Categories:
Type: BOOK - Published: 2017 - Publisher:
Stroke and traumatic brain injury (TBI) are leading causes of death and long-term disability worldwide. Despite the socioeconomic burden of these neural injuries, there are no restorative therapies. Induced pluripotent stem cell-derived neural stem cells (iNSCs) may be the critically needed therapy to restore neurological function after brain injury. Preclinical
Improvements Implemented and Planned by the Department of Defense and the Department of Veterans Affairs for the Care, Management, and Transition of Wounded and Ill Servicemembers
Language: en
Pages: 94
Authors: United States. Congress. Senate. Committee on Armed Services
Categories: Disabled veterans
Type: BOOK - Published: 2008 - Publisher:
Books about Improvements Implemented and Planned by the Department of Defense and the Department of Veterans Affairs for the Care, Management, and Transition of Wounded and Ill Servicemembers
Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2014
Language: en
Pages:
Authors: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Categories: Administrative agencies
Type: BOOK - Published: 2013 - Publisher:
Books about Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2014
Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2013
Language: en
Pages:
Authors: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Categories: Administrative agencies
Type: BOOK - Published: 2012 - Publisher:
Books about Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2013
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Language: en
Pages:
Authors: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Categories: Medicine
Type: BOOK - Published: 1994 - Publisher:
Books about Biomedical Index to PHS-supported Research
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Language: en
Pages:
Authors: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Categories: Medicine
Type: BOOK - Published: 2004 - Publisher:
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Language: en
Pages: 313
Authors: Surya Mallapragada, Balaji Narasimhan
Categories: Biodegradable plastics
Type: BOOK - Published: 2006 - Publisher:
Books about Handbook of Biodegradable Polymeric Materials and Their Applications: Applications
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Language: en
Pages:
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Categories: Genetic engineering
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Language: en
Pages:
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Categories: Dissertations, Academic
Type: BOOK - Published: 2008 - Publisher:
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Perinatal Stem Cells
Language: en
Pages: 418
Authors: Anthony Atala, Kyle J. Cetrulo, Rouzbeh R. Taghizadeh, Curtis L Cetrulo, Sean Murphy
Categories: Science
Type: BOOK - Published: 2018-06-14 - Publisher: Academic Press
Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed