Effects Of Mild Traumatic Brain Injury On Hippocampal Synaptic Plasticity And Behaviour In Juvenile Rats

Effects Of Mild Traumatic Brain Injury On Hippocampal Synaptic Plasticity And Behaviour In Juvenile Rats by Cristina Pinar Cabeza de Vaca. Download it Effects Of Mild Traumatic Brain Injury On Hippocampal Synaptic Plasticity And Behaviour In Juvenile Rats books also available in PDF, EPUB, and Mobi Format for read it on your Kindle device, PC, phones or tablets. R-mTBI in juvenile populations is of special interest as not only is this a high risk group, but this is also a time period when the human brain continues to mature.. Click Get Books for free books.

Effects Of Mild Traumatic Brain Injury On Hippocampal Synaptic Plasticity And Behaviour In Juvenile Rats

Effects Of Mild Traumatic Brain Injury On Hippocampal Synaptic Plasticity And Behaviour In Juvenile Rats
Author: Cristina Pinar Cabeza de Vaca
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Traumatic Brain Injury (TBI) is a global health problem and concussion, or mild TBI (mTBI), accounts for up to 75% of all brain injuries occurring annually in the US. There is also growing awareness that repeated mild traumatic brain injury (r-mTBI) can result in cumulative neuropathology and learning and memory deficits, however there is a paucity of preclinical data as to the extent these deficits manifest. R-mTBI in juvenile populations is of special interest as not only is this a high risk group, but this is also a time period when the human brain continues to mature. The hippocampus is a brain region important for learning and memory processes, and r-mTBI during the juvenile period may particularly disrupt the development of cognitive processes. To examine this issue we used a model of awake closed head injury (ACHI), and administered 8 impacts over a 4 day period to juvenile male and female rats (P25-28). At 1 or 7 days after the last injury, a cohort of rats was used for behavioural testing to study anxiety and risk-taking behaviours and cognitive abilities. From a different cohort, hippocampal slices were generated and used for in vitro electrophysiological recordings, and the capacity for long-term depression (LTD) and long-term potentiation (LTP) was examined in the medial perforant path (MPP)-dentate gyrus (DG) synapse. Our results showed that r-mTBI impaired hippocampal-dependent spatial learning and memory and that r-mTBI significantly impaired the capacity for LTD but not LTP in both sexes. These data are the first to describe the negative impact of r-mTBI on LTD in the juvenile DG in both males and females, and provide evidence for the delayed development of neurological deficits with r-mTBI.